Discussion questions for recitations

Week 13

  • Any reason to think that a DNA vaccine might be more effective in individuals with a “weaker” immune system?

  • The Oxford/Astrazeneca vaccine is a viral-vector vaccine that uses an adenovirus to get spike-protein DNA into a subject’s cell nuclei. Some people have proposed a hybrid regimen of giving one shot of this vaccine and one shot of an mRNA vaccine. Any idea why that might be more effective than two shots of the Oxford/Astrazeneca vaccine?

  • The new DNA and RNA vaccines feature a fast turnaround time from the appearance of a new virus to volume vaccine manufacturing. Some people have argued that this represents the most important scientific achievement of the last 100 years. What do you think?